1. First, the ideal hemostatic agent would of course be such that the agent itself is as well as any of its metabolic breakdown products would be safe to use within the body.
2. Second, you want it to work and you want it to be efficacious.The definition of efficacy can vary between the different uses, for example a vascular surgeon may want something that polymerizes very quickly in order to stop bleeding, but does not cause clot of the vessel that they spent all this time anastomosing, where as a reconstructive surgeon for example may want something that polymerizes very slowly to give them time to reposition their flaps or grafts.
3. Third is usability; you want something that is easy to use and that you can use in a variety of different circumstances.
4. Fourth is affordability. This may be more relevant to a hospital administrator or pharmacist who actually does the purchasing, but it impacts the surgeon because that determines what you have available to you in the operating room.
5. And finally, fifth, approvability. Any of these agents need to be approved by the FDA in order to be used in the US.
No comments:
Post a Comment